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The efficacy assessment of 154 cases of recurrent/metastatic head and neck squamous cell carcinoma patients treated with first-line PD-1 inhibitors in combination with a taxane-based chemotherapy

Journal: World Journal of Surgical Oncology

Article Title: The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study

doi: 10.1186/s12957-024-03644-7

Figure Lengend Snippet: The efficacy assessment of 154 cases of recurrent/metastatic head and neck squamous cell carcinoma patients treated with first-line PD-1 inhibitors in combination with a taxane-based chemotherapy

Article Snippet: China International Medical Exchange Foundation, Simcere Anti-Tumor Special Fund Clinical Project, Intratumoral Injection of Recombinant Human Endostatin Combined with Chemotherapy for the Treatment of Exophytic Recurrent and Metastatic Malignant Tumors of the Head and Neck, Registration Number: ChiCTR1900022364; Project Number: Z-2014-06-18384.

Techniques:

The progression-free survival rate of 154 cases of recurrent/metastatic head and neck squamous cell carcinoma patients treated with first-line PD-1 inhibitors in combination with a taxane-based chemotherapy

Journal: World Journal of Surgical Oncology

Article Title: The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study

doi: 10.1186/s12957-024-03644-7

Figure Lengend Snippet: The progression-free survival rate of 154 cases of recurrent/metastatic head and neck squamous cell carcinoma patients treated with first-line PD-1 inhibitors in combination with a taxane-based chemotherapy

Article Snippet: China International Medical Exchange Foundation, Simcere Anti-Tumor Special Fund Clinical Project, Intratumoral Injection of Recombinant Human Endostatin Combined with Chemotherapy for the Treatment of Exophytic Recurrent and Metastatic Malignant Tumors of the Head and Neck, Registration Number: ChiCTR1900022364; Project Number: Z-2014-06-18384.

Techniques:

The overall survival rate of 154 cases of recurrent/metastatic head and neck squamous cell carcinoma patients treated with first-line PD-1 inhibitors in combination with a taxane-based chemotherapy

Journal: World Journal of Surgical Oncology

Article Title: The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study

doi: 10.1186/s12957-024-03644-7

Figure Lengend Snippet: The overall survival rate of 154 cases of recurrent/metastatic head and neck squamous cell carcinoma patients treated with first-line PD-1 inhibitors in combination with a taxane-based chemotherapy

Article Snippet: China International Medical Exchange Foundation, Simcere Anti-Tumor Special Fund Clinical Project, Intratumoral Injection of Recombinant Human Endostatin Combined with Chemotherapy for the Treatment of Exophytic Recurrent and Metastatic Malignant Tumors of the Head and Neck, Registration Number: ChiCTR1900022364; Project Number: Z-2014-06-18384.

Techniques:

Kaplan-meier curves for univariate analysis of clinical characteristics in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with pd-1 inhibitors in combination with a taxane-based chemotherapy. Note (A) : Comparison of PFS survival curves based on the presence or absence of distant metastasis; (B) : Comparison of OS survival curves based on the presence or absence of distant metastasis; (C) : Comparison of PFS survival curves based on whether subsequent radiotherapy was administered; (D) : Comparison of OS survival curves based on whether subsequent radiotherapy was administered; (E): Comparison of PFS survival curves based on whether radiotherapy was administered before recurrence/metastasis; (F) : Comparison of OS survival curves based on whether radiotherapy was administered before recurrence/metastasis;

Journal: World Journal of Surgical Oncology

Article Title: The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study

doi: 10.1186/s12957-024-03644-7

Figure Lengend Snippet: Kaplan-meier curves for univariate analysis of clinical characteristics in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with pd-1 inhibitors in combination with a taxane-based chemotherapy. Note (A) : Comparison of PFS survival curves based on the presence or absence of distant metastasis; (B) : Comparison of OS survival curves based on the presence or absence of distant metastasis; (C) : Comparison of PFS survival curves based on whether subsequent radiotherapy was administered; (D) : Comparison of OS survival curves based on whether subsequent radiotherapy was administered; (E): Comparison of PFS survival curves based on whether radiotherapy was administered before recurrence/metastasis; (F) : Comparison of OS survival curves based on whether radiotherapy was administered before recurrence/metastasis;

Article Snippet: China International Medical Exchange Foundation, Simcere Anti-Tumor Special Fund Clinical Project, Intratumoral Injection of Recombinant Human Endostatin Combined with Chemotherapy for the Treatment of Exophytic Recurrent and Metastatic Malignant Tumors of the Head and Neck, Registration Number: ChiCTR1900022364; Project Number: Z-2014-06-18384.

Techniques: Comparison

Multifactorial analysis of progression-free survival in 154 cases of recurrent/metastatic squamous cell carcinoma of the head and neck treated with first-line pd-1 inhibitors combined with a taxane-based chemotherapy

Journal: World Journal of Surgical Oncology

Article Title: The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study

doi: 10.1186/s12957-024-03644-7

Figure Lengend Snippet: Multifactorial analysis of progression-free survival in 154 cases of recurrent/metastatic squamous cell carcinoma of the head and neck treated with first-line pd-1 inhibitors combined with a taxane-based chemotherapy

Article Snippet: China International Medical Exchange Foundation, Simcere Anti-Tumor Special Fund Clinical Project, Intratumoral Injection of Recombinant Human Endostatin Combined with Chemotherapy for the Treatment of Exophytic Recurrent and Metastatic Malignant Tumors of the Head and Neck, Registration Number: ChiCTR1900022364; Project Number: Z-2014-06-18384.

Techniques:

Multifactorial analysis of overall survival in 154 cases of recurrent/metastatic squamous cell carcinoma of the head and neck treated with first-line pd-1 inhibitors combined with a taxane-based chemotherapy

Journal: World Journal of Surgical Oncology

Article Title: The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study

doi: 10.1186/s12957-024-03644-7

Figure Lengend Snippet: Multifactorial analysis of overall survival in 154 cases of recurrent/metastatic squamous cell carcinoma of the head and neck treated with first-line pd-1 inhibitors combined with a taxane-based chemotherapy

Article Snippet: China International Medical Exchange Foundation, Simcere Anti-Tumor Special Fund Clinical Project, Intratumoral Injection of Recombinant Human Endostatin Combined with Chemotherapy for the Treatment of Exophytic Recurrent and Metastatic Malignant Tumors of the Head and Neck, Registration Number: ChiCTR1900022364; Project Number: Z-2014-06-18384.

Techniques:

A Fluorescence intensity at various time points following iMSC Endostatin recognition of tumors. B The endostatin-mCherry released by iMSC Endostatin at different time points was detected by a microplate reader. C The microplate reader was utilized to detect the total amount of endostatin-mCherry accumulated every four hours following full activation of iMSC Endostatin . D The amount of released endostatin by iMSC Endostatin was quantified using ELISA detection.

Journal: Cell Death & Disease

Article Title: Intelligent drugs based on notch protein remodeling: a defensive targeting strategy for tumor therapy

doi: 10.1038/s41419-024-07008-7

Figure Lengend Snippet: A Fluorescence intensity at various time points following iMSC Endostatin recognition of tumors. B The endostatin-mCherry released by iMSC Endostatin at different time points was detected by a microplate reader. C The microplate reader was utilized to detect the total amount of endostatin-mCherry accumulated every four hours following full activation of iMSC Endostatin . D The amount of released endostatin by iMSC Endostatin was quantified using ELISA detection.

Article Snippet: ELISA: MSCs or iMSC Endostatin will be co-cultured with Skov3-GFP for 48 h, and MSCs and iMSC Endostatin cells will be sorted by flow cytometry and cultured in a 24-well plate coated with fibronectin for 24 h. The content of endostatin will be detected using an ELISA detection kit (CSB-E07973h; CUSABIO).

Techniques: Fluorescence, Activation Assay, Enzyme-linked Immunosorbent Assay